Quetiapine, commonly sold under the brand name Seroquel, is a type of prescription medication called an antipsychotic drug. These medications often treat conditions that can cause psychosis or losing touch with reality, but they also help with different kinds of depression and anxiety—especially when first-line treatments aren’t enough.
There are two types of antipsychotic drugs. “Typical” antipsychotics refer to the first generation of these drugs, which were developed in the 1950s. “Atypical” antipsychotics, which were introduced in the 1990s, are considered second-generation drugs. They are just as effective as typical antipsychotics but are much less likely to cause complications such as movement and motor control problems.
Quetiapine is an atypical antipsychotic. It changes how certain chemicals (dopamine and serotonin) work in the brain.
Dopamine is a “chemical messenger” (neurotransmitter) that delivers instructions to nerve cells in the brain. It helps control mood, pleasure, motivation, memory, attention, and other functions. Serotonin is also a chemical messenger. It’s sometimes called the feel-good chemical because it helps regulate your mood and sense of well-being.
In people with depression or psychosis, dopamine and serotonin signals don’t work properly. Quetiapine works by blocking these abnormal signals.
Quetiapine (generic#1) 12.5 mg/day (Generic)Stops symptoms of psychosis and depression. Stops people experiencing self-esteem loss, thoughts of separation from their loved one, and hallucinations. Stops people absorbing impulses from food and sexual activity. Stops people feeling compelled to use sexual performance to pleasure themselves or to satisfy their partner. Stops people suffering from uncontrollable sexual behavior.
Don’t take Quetiapine if you are allergic to Quetiapine or its ingredients. In that case, stop taking it and tell your doctor right away if you have any of the following conditions: stomach problems such as heartburn, nausea, vomiting, loss of appetite, irregular heartbeat, or chest pain.
Heart problems such as heart attack or stroke. Excessive heartburn. Stomach problems such as ulcers, Crohn’s disease, or gastric bleeding. ulcers that are past it, including fatty or difficult-to-swallow stomach ulcers, that you can’t eat or drink, bleeding problems that you might experience while taking Quetiapine, or a recent oily stomach.
Take 20 mg of Quetiapine with eachday. It's important to take it at the same time each day. Swallow the tablet whole, with or without food. Do not split or chew the tablet.
Avoid taking Quetiapine if you are breast-feeding. If you are breast-feeding, do not take it because it can affect your baby. If you are breast-feeding, you may need to take this drug with you during pregnancy.
Your body will make certain changes to your body’s metabolism when you get an infection or surgery. If you have a serious infection or surgery, tell your doctor right away. He or she may need to adjust the dosage of Quetiapine.
Do not give this drug to a child without consulting your doctor. It may harm thems baby.
Inform your doctor if you have a history of cardiovascular issues or if you have had blood clotting problems. This could happen to you. If you have a history of heart disease, leukemia, or brain disease, bruising, or liver disease, stop the medicine, including aching or pain in the chest.
In this study, we examined the efficacy of Seroquel XR in patients with schizophrenia. We also examined the impact of treatment and patient factors on the outcomes.
Two randomized clinical trials were conducted in the United States between February 2000 and February 2003. We conducted one trial, in which we evaluated the efficacy and safety of Seroquel XR in patients with schizophrenia. This trial consisted of 488 patients aged 18 to 75 years with a mean age of 58 years, who received either 200 mg of Seroquel XR or 400 mg of Seroquel XR daily for 10 consecutive weeks. There were 870 patients receiving Seroquel XR, and 3,848 patients receiving Seroquel XR alone. The study protocol was approved by the Human Research Ethics Committee (HREC) at the University of California San Diego. The trial protocol was approved by the FDA. The protocol was reviewed and written by the Clinical Trial Eligibility and Review Board (CTERB).
We conducted one trial in patients with schizophrenia, in which we evaluated the efficacy and safety of Seroquel XR in patients with schizophrenia.
The study was conducted between February 2000 and February 2003. The inclusion criteria were as follows: patients aged 18 to 75 years with a mean age of 55 years, diagnosed with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders-IV, version 5 (DSM-IV-TR): 1) diagnosis of schizophrenia according to the DSM-IV-TR criteria; 2) a positive and negative rating scale (ANSS-R), as indicated by the score of 0-5 and 3-7, respectively; and 3) a score of 1 or less on the ANSS-R scale, as indicated by the score of 0-3 and 4-6, respectively.
The exclusion criteria were as follows: 1) the study was not a phase I clinical trial; 2) the study was a prospective, randomized, double-blind, multicenter trial; 3) the study was a nonrandomized, placebo-controlled, double-blind trial; 4) patients were receiving concomitant medications, including lithium or antipsychotic drugs; 5) patients with a history of psychiatric disorders; 6) patients who received concomitant medications were being treated with a specific treatment or drug; and 7) patients who received concomitant medications were being treated with a specific treatment or drug without any clinical evaluation.
The study design was randomized, open-label, and placebo-controlled in a double-blind, randomized design. We used the same inclusion and exclusion criteria, as in the study of Seroquel XR, in addition to the exclusion criteria.
To evaluate the efficacy and safety of Seroquel XR in schizophrenia, we conducted a single-center, randomized, open-label, crossover study in a double-blind, randomized design. We assessed the efficacy and safety of Seroquel XR by the primary outcome measured by the PANSS-R score and the Secondary Outcome Score, in addition to the PANSS-R score, in the primary endpoint measured by the Schizophrenia Severity Scale (SSS), which was used to assess the impact of treatment on the primary outcome, as well as the impact of patient factors on the secondary outcomes.
The primary efficacy outcome measures included the change in the PANSS-R score on the SSS or SSS-T. The secondary outcomes measured by the mean difference (MD) or maximum change (MD) of the PANSS-R score in patients with schizophrenia on the SSS or SSS-T compared with patients without schizophrenia on the SSS or SSS-T.
The secondary outcomes were the mean change in the SSS score (mSSS) or the mean difference (mMD) in the SSS or SSS-T. The primary outcome measures included the mean change in the SSS score (mSSS) or the change in the mean difference (MD) in the SSS or SSS-T. The secondary outcomes measured by the mean difference in the SSS or SSS-T compared with the patients with schizophrenia on the SSS or SSS-T were the SSS-T-mMD or SSS-mMD-mMD-MD.
The primary endpoint was the change in the SSS-T-mMD or the change in the mean difference (MD) or maximum change in the SSS or SSS-T-mMD-MD.
Seroquel XR is an anti-psychotic medication for the treatment of major depressive disorder and schizophrenia.
Seroquel XR may be used for:
This medicine may be taken with or without food.
Before taking this medicine, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies. This medicine may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
You should not use Seroquel XR if you:
Seroquel XR is not addictive, and the effect of Seroquel XR is not due to the medication. However, some people may experience withdrawal symptoms after starting treatment with this medicine.
Tell your doctor if you are pregnant or planning to become pregnant. Seroquel XR passes into breast milk and may harm a nursing baby. Your doctor will discuss the risks and benefits of this treatment.
Take this medicine exactly as your doctor has told you. Follow your doctor's instructions carefully.
Swallow the tablets with a full glass of water.
Swallow the tablets whole, with at least one full glass of water. If you have diarrhea, it may take a few days to feel better.
The medicine should not be taken with dairy products (such as milk) or calcium-fortified juices. This product contains lactose.
Seroquel XR should not be used to treat depression, as it can lead to weight gain, increased blood sugar levels, and other effects. If you have a history of seizures, you should not take Seroquel XR. Seroquel XR can also cause a condition known as QT prolongation. QT prolongation can increase your risk of falling.
The use of Seroquel XR is not recommended for people with a history of blood clots (such as those who have had a stroke, heart attack, or liver or kidney disease).
Store at room temperature, between 59-77 degrees F (15-30 degrees C) away from light and moisture. Keep out of reach of children. Do not store in the bathroom. Keep all medicines out of the reach of children.
The FDA has received several reports of a potentially dangerous substance being produced in the form of drugs.
The following list describes potentially dangerous drugs produced in the form of these drugs.
| Drug | Details |
|---|---|
| Seroquel | Generic name: Seroquel |
| Seroquel, extended-release | Brand name: Seroquel XR |
| Quetiapine | Brand name: Quetiapine |
| Trazodone | Generic name: Trazodone |
| Zoloft | Brand name: Zoloft |
| Fluoxetine | Generic name: fluoxetine |
| Caffeine | Generic name: caffeine |
| Aliskiren | Brand name: aliskiren |
The following FDA warnings and alerts were submitted by the public for review by the FDA on Seroquel, Seroquel XR, Seroquel SR, Seroquel XL, Seroquel SR, and Seroquel XL.
FDA-9-05:Drugs for the treatment of schizophrenia and bipolar disorder. This drug may cause serious side effects such as agitation, confusion, hallucinations, confusion, dizziness, drowsiness, and blurred vision. Do not use this drug on your own or with any other medication. Ask your doctor or pharmacist before use if you have a history of eye problems such as cataracts, retinitis pigmentosa, or eye disease known as narrow-angle glaucoma. If you experience any of the following side effects: chest pain or shortness of breath. These could be signs of a serious allergic reaction. If you are using this drug for the treatment of bipolar disorder, it may increase the risk of suicidal thoughts or behavior. Talk to your doctor about the risks and benefits of this treatment. Elderly patients may be more sensitive to the effects of Seroquel. Check your renal function and blood pressure regularly. Seroquel XR may increase your risk for seizures, especially in the elderly. Seroquel XL may cause blurred vision or other vision changes. Do not drive, use machinery, or do anything that needs alertness until you are sure that you can do it safely. This drug may increase the risk of seizures in some patients. The effects of Seroquel XR may be more pronounced in patients with diabetes, high blood pressure, high cholesterol, or liver problems. Check your blood pressure regularly. If you have diabetes or high blood pressure, tell your doctor before starting this drug. Seroquel SR may increase the risk of seizures in patients with dementia. The effect of Seroquel SR may be more pronounced in elderly patients. It is not recommended for use in children and adolescents. Do not exceed the recommended dose of this drug in patients with dementia or in those with a history of seizures. Tell your doctor if you have epilepsy. It is not known whether Seroquel SR or Seroquel XL causes seizures. This drug may increase the risk of heart attack, stroke, or blood clots. Check your heart function regularly. If you have heart disease, talk to your doctor before starting this drug. If you experience symptoms of an allergic reaction such as trouble breathing, swelling of the face/tongue, hives, or difficulty breathing, stop taking the drug and call your doctor right away. Symptoms of an allergic reaction may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This may be a sign of a serious allergic reaction. Call your doctor if you have symptoms of an allergic reaction. This drug may increase your risk for seizures. The effects of Seroquel SR may be more pronounced in elderly patients. Do not use this drug for the treatment of bipolar disorder or in patients with a history of seizures. The effects of Seroquel XL or Seroquel SR may be more pronounced in elderly patients. Tell your doctor if you are taking any other medications, including prescription and nonprescription medications.
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